Table 6.
Comparison of amino acid changes in viral proteins between wild and vaccine strains from the 30 corresponding sites in TW2575/98 and the other 5 IB viruses
| Proteins | TW2575/98 | TW2296/95 | ArkDPI | Mass | GA98 | CK/CH/LDL/971 |
|---|---|---|---|---|---|---|
| P87 | F53La | (F)b | (F) | (F) | (F) | (F) |
| A150V | (A) | (A) | (A) | (A) | (A) | |
| I285V | (I) | (I) | (I) | (I) | (I) | |
| V342D | (V) | (V) | (V) | (V) | (V) | |
| L354P | (L) | (L) | (L) | (L) | (L) | |
| AC domain | I829Ne | (N) | (N) | (N) | (N) | (N) |
| G832Pe | (P) | (P) | (P) | (P) | (P) | |
| PL1pro | G951Ee | (E) | (A) | –c → Ed | (E) | (D) |
| PL2 pro | V1280Ie | (V) | (V) | (V) | (V) | (I) |
| HD1 | S1493P | (S) | (S) | (S) | (S) | (S) |
| A1693Ve | (F) | (V) | (V) | (V) | (V) | |
| P2025S | Y → Hd | (H) | (H) | (H) | (H) | |
| F2308Y | (F) | (F) | (F) | (F) | (F) | |
| 3CLpro | W2831Ge | (G) | (G) | (G) | (G) | (G) |
| HD2 | I3204V | (I) | (I) | (I) | (I) | (I) |
| K3346N | (K) | (K) | (K) | (K) | (K) | |
| GLF | G3833De | (D) | (D) | (D) | (D) | (D) |
| RdRp | F453Ve | (V) | (V) | (V) | (V) | (V) |
| L474P | (L) | (L) | (L) | (L) | (L) | |
| nsp10 | P1356L | (P) | (P) | (P) | (P) | (P) |
| nsp11 | Y1859He | (H) | (H) | (H) | (H) | (H) |
| S1 | P56Te | (L) | (N) | (S) | (S) | (T) |
| A94Se | (S) | (S) | (S) | (V) | (S) | |
| S2 | E585G | (E) | (E) | (E) | (D) | (E) |
| L595F | (L) | (L) | (L) | (L) | (L) | |
| N612I | (N) | (N) | (N) | (N) | (N) | |
| M | E4Ve | (V) | (M) | (E) | (E) | (S) |
| S11Fe | (T) | (L) | (F) | (F) | (T) | |
| R182C | (R) | (R) | (R) | (R) | (R) | |
| 5a | F7C | (F) | (F) | (F) | (F) | (L) |
aAmino acid changes in the specific site of residue
bAmino acid in parentheses stands for none of the alterations between wild and vaccine strains
cDash means none of the amino acids existed in the site
dMeans the substitution of amino acid from wild to vaccine strains
eIndicates the 13 sites were found that at least one of the other 5 IBVs’ wild strains has the same amino acid residue in TW2575/98vac