Table 2.
Response to treatment with ruxolitinib
Parameter | aGVHD, n = 10 | cGVHD, n = 28 |
Overall response rate, n (%) | 10 (100) | 22 (82.1) |
Median follow-up time in mo, median (range) | 2.5 (1.5–4) | 5 (1.5–10) |
Time to best overall response in mo, median (range) | 1.0 (0.5–2.5) | 3.0 (1.0–9.5) |
Time to best response for each organ system in d, median (range) | ||
Skin | 28 (14–28) | 77 (7–147) |
Digestive tract | 25 (14–60) | 259 (70–308) |
Liver | 32 (21–42) | 42 (28–56) |
Eye | - | 112 (42–182) |
Oral cavity | - | 80 (28–168) |
Lung | - | 91 (49–140) |
Fascia | - | 91 (56–266) |
Discontinuation of immunosuppressive agents after ruxolitinib, n (%) | 8 (80.0) | 21 (75.0) |
aGVHD: Acute graft-vs-host disease; cGVHD: Chronic graft-vs-host disease.