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. 2012 Nov 8;2(5):1187–1196. doi: 10.1016/j.celrep.2012.10.005

Figure 1.

Figure 1

MDA5 Recognizes Picornaviruses across Various Genera

(A) MEFs of indicated genotypes were either infected with mengo-Zn (MOI 50) or transfected with virion RNA (vRNA) from WT mengovirus. IFN-β promoter activation at 8 hr.p.t. was determined by an IFN reporter assay.

(B) MEFs of indicated genotypes were transfected with vRNAs from three human enteroviruses (HEVs), namely enterovirus 71, coxsackievirus B3, or coxsackievirus A21, a close relative to poliovirus. IFN-β promoter activation at 8 hr.p.t. was determined by IFN reporter assay.

(C) Same assay as (B) using vRNAs from Saffold virus 3, human parechovirus 1, and equine rhinitis A virus. Data presented as mean ± SD.

See also Figure S1.