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. 2020 Mar 18;2020:9132720. doi: 10.1155/2020/9132720

Figure 8.

Figure 8

Treadmill exercise reversed hyperexcitability in APP/PS1 mice. EEG recordings showed increased brain activity amplitudes and frequencies of sedentary APP/PS1 mice in early 12-week (a), late 12-week (b), and 24-week (c) groups, which was partially reversed in the APP/PS1 mice treated with 12- and 24-week treadmill exercises. The percentage of time at high frequency (>6 Hz) was also recorded, analyzed, and indicated by histograms; exercised APP/PS1 mice exhibited shorter durations of high-frequency activity than the sedentary mice, but the levels did not reach WT levels. WT: wild type; SC: sedentary control; TE: treadmill exercise. ∗WT vs. TE, P < 0.05; #WT vs. SC, P < 0.05; &TE vs. SC, P < 0.05.