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Treadmill exercise redressed aberrant sodium channel expression in APP/PS1 mice. Hippocampal Nav expression levels were detected in mice in the early 12-week (a), late 12-week (b), and 24-week (c) groups. Aberrant Nav expression was observed in APP/PS1 mice with different ages, which were altered following 12- or 24-week treadmill exercise. WT: wild type; SC: sedentary control; TE: treadmill exercise. ∗WT vs. TE, P < 0.05; #WT vs. SC, P < 0.05; &TE vs. SC, P < 0.05.
