Table 3.
The total object exploration time in NOR test.
| Grouping of APP/PS1 mice | Exploration time (%) | Total exploration time for both objects (min) | |||
|---|---|---|---|---|---|
| Familiar | Novel | ||||
| Early 12-week | WT | 2 m | 40 ± 2.8 | 60 ± 3.4 | 7.3 ± 1.3 |
| 3.5 m | 42 ± 3.9 | 58 ± 4.1 | 8.5 ± 1.1 | ||
| 5 m | 38 ± 4.8 | 62 ± 4.1 | 7.7 ± 2.9 | ||
| Sedentary control | 2 m | 52 ± 3.4 | 48 ± 2.1 | 8.3 ± 1.9 | |
| 3.5 m | 55 ± 2.8 | 45 ± 2.6 | 7.9 ± 2.8 | ||
| 5 m | 59 ± 3.7 | 41 ± 1.5 | 6.8 ± 2.4 | ||
| Treadmill exercise | 2 m | 58 ± 2.5 | 52 ± 1.5 | 6.7 ± 2.2 | |
| 3.5 m | 51 ± 1.9 | 49 ± 2.5 | 7.4 ± 1.1 | ||
| 5 m | 55 ± 4.2 | 45 ± 3.2 | 8.3 ± 2.1 | ||
|
| |||||
| Late 12-week | WT | 6.5 m | 42 ± 3.6 | 58 ± 3.2 | 8.8 ± 1.2 |
| 8 m | 44 ± 4.9 | 56 ± 4.1 | 9.1 ± 3.2 | ||
| 9.5 m | 47 ± 3.1 | 53 ± 2.2 | 7.6 ± 2.7 | ||
| Sedentary control | 6.5 m | 61 ± 5.1 | 39 ± 4.8 | 7.7 ± 2.4 | |
| 8 m | 64 ± 5.9 | 36 ± 6.2 | 8.4 ± 3.4 | ||
| 9.5 m | 69 ± 8.2 | 31 ± 3.7 | 7.6 ± 2.4 | ||
| Treadmill exercise | 6.5 m | 55 ± 3.6 | 45 ± 2.3 | 7.2 ± 2.8 | |
| 8 m | 62 ± 5.4 | 38 ± 3.4 | 8.1 ± 3.5 | ||
| 9.5 m | 67 ± 6.9 | 33 ± 5.2 | 8.4 ± 2.6 | ||
|
| |||||
| 24-week | WT | 2 m | 40 ± 2.7 | 60 ± 6.4 | 8.3 ± 2.6 |
| 3.5 m | 42 ± 3.1 | 58 ± 5.1 | 7.8 ± 1.9 | ||
| 5 m | 41 ± 3.3 | 59 ± 5.6 | 8.9 ± 3.1 | ||
| Sedentary control | 2 m | 59 ± 5.9 | 41 ± 4.3 | 7.7 ± 3.4 | |
| 3.5 m | 61 ± 8.1 | 39 ± 6.1 | 8.2 ± 4.1 | ||
| 5 m | 65 ± 7.2 | 35 ± 5.7 | 7.5 ± 2.7 | ||
| Treadmill exercise | 2 m | 48 ± 5.1 | 52 ± 3.2 | 8.6 ± 2.7 | |
| 3.5 m | 52 ± 3.7 | 48 ± 3.6 | 7.9 ± 1.8 | ||
| 5 m | 54 ± 6.6 | 46 ± 4.7 | 7.3 ± 2.8 | ||
2 m, 2-month-old; 3.5 m, 3.5-month-old; 5 m, 5-month-old; 6.5 m, 6.5-month-old; 8 m, 8-month-old; 9.5 m, 9.5-month-old. The age of the mice in the table corresponds to the age at the beginning of the study.