Figure 2.

Percentage of the major cytogenetic subgroups of acute myeloid leukemia (AML) (excluding acute promyelocytic leukemia), and associated gene mutations. In the subgroup with various karyotypes, NPM1 mutations are frequently found in AML with 9q deletion and trisomy 8, CEBPA mutations in AML with 9q deletion, MLL mutations in AML with trisomy 11, and RUNX1 mutations in AML with trisomy 13 and trisomy 21 (frequencies of the cytogenetic subgroups are taken from Reference 36, derived from 2654 cytogenetically characterized adults (≥18 years) with de novo or secondary AML entered on AMLSG treatment trials).

Note: Data from Chiaretti et al.¹