Figure 5.
BP-based scaffolds can eliminate osteosarcoma and enhance bone regeneration. (A) Schematic illustration of the fabrication process for BP-BG scaffolds and the stepwise therapeutic strategy. (B) Time-dependent tumor-growth curves of the mice after different treatments as described in the figure. (C) Photographs of osteosarcoma-bearing mice after different treatments on day 14, the yellow circle and black arrow indicate the location of the tumor. (D) Micro-CT images of the cranium based on the density variations of osseous tissue. (E) The percentage of newborn osseous tissue volume over the entire defect space (*p < 0.05). Reproduced with permission from Yang B, Yin J, Chen Y. et al. 2D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma. Adv Mater. 2018;30(10). Copyright 2018, Wiley-VCH.27
Abbreviations: BG, bioglass; BP, black phosphorus; BV, bone volume; CaP, calcium phosphate; NIR, near-infrared; TV, tissue volume.