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. 2020 Mar 25;15:2059–2070. doi: 10.2147/IJN.S240449

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© 2020 Liu et al.

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Characterization of SMEDDS. FA-SMEDDS showed small droplet size, good stability, and promoted release trait. Morphological feature (× 30,000; (A) and size distribution of FA microemulsion (B). Stability of FA microemulsion evaluated by storing in ambient conditions for 30 days: changes of appearance vs time at 25°C (C) and 37 °C (D). In vitro profiles of FA-SMEDDS and FA in dissolution media, including pH1.2 (E), pH6.8 (F), and water (G). *P < 0.05; **P < 0.01, vs FA-control group, Independent samples t-test.