Table 3.
Analysis of Distributed Tendency of FA in the Tissues. (n=6)
| FA | FA-SMEDDS | RE (-folds) | |||
|---|---|---|---|---|---|
| AUC0-t (h·μg/mL) | DP (%) | AUC0-t (h·μg/mL) | DP (%) | ||
| Heart | 34.48 ± 4.36 | 4.6 ± 0.8 | 54.33 ± 27.87 | 5.5 ± 2.7 | 1.20 ± 0.59 |
| Liver | 71.24 ± 16.61 | 9.3 ± 1.6 | 123.94 ± 25.40** | 12.9 ± 3.2* | 1.39 ± 0.35 |
| Spleen | 13.21 ± 4.53 | 1.8 ± 0.8 | 34.54 ± 13.32* | 3.6 ± 1.5* | 1.98 ± 0.81 |
| Lung | 57.41 ± 11.65 | 7.6 ± 1.7 | 77.69 ± 20.34 | 8.2 ± 2.8 | 1.08 ± 0.37 |
| Kidney | 583.68 ± 97.91 | 76.1 ± 3.4 | 585.86 ± 134.70 | 59.4 ± 7.7** | 0.78 ± 0.10 |
| Brain | 4.70 ± 1.83 | 0.7 ± 0.4 | 99.76 ± 14.04** | 10.4 ± 2.3** | 14.87 ± 3.34 |
| Total | 764.72 ± 104.04 | 100 | 976.12 ± 104.47 | 100 | — |
Notes: These results indicate that SMEDD change the distribution tendency of FA. *P < 0.05; **P < 0.01, vs FA group.
Abbreviations: AUC, Area under the concentration–time curve; DP, Distribution percentage; RE, Relative intake efficiency.