. 2019 Nov 25;63(6):2789–2801. doi: 10.1021/acs.jmedchem.9b01518

Table 2. Biochemical and Microbiological Activity of BLIs 18–23.

							microbiological assay, MIC (μg/mL)^a
			biochemical assay, IC₅₀ (μM)^b				K. pneumoniae			P. aeruginosa
entry	clogP	tPSA	KPC-2 (class A)	AmpC (class C)	OXA-48 (class D)	VIM-2 (class B)	KPC-2	OXA-48	VIM-4	VIM-2
18	–1.85	145	0.019	0.006	3.14	2.4	4	8	32	16
19	–1.99	128	0.017	0.01	7.55	1.4	2	2	0.5	4
20	–2.39	134	0.03	0.032	0.42	0.02	0.5	2	0.5	0.06
21	–1.32	111	0.02	0.003	1.52	1.5	4	16	32	16
22	–2.39	134	0.03	0.035	0.67	0.13	8	8	4	0.5
23	–1.81	134	0.022	0.005	0.288	0.491	1	1	8	0.5

Reported as the BLI concentration able to restore meropenem (fixed at 4 μg/mL) antibacterial activity.

Results are expressed as the average from duplicates unless otherwise indicated.