Table 9. Rescue of Cefepime Activity by BLI (Fixed at 4 μg/mL) in 14 Gram-Negative Pathogens Expressing Class B Enzymesa.
| entry | MIC range (μg/mL)b | MIC50 (μg/mL) | MIC90 (μg/mL) | % of strains with MICs ≤8c |
|---|---|---|---|---|
| cefepime | 32 to >512 | >512 | >512 | 0 |
| cefepime/20 | 0.125–4 | 1 | 4 | 100 |
| cefepime/TZB | 16 to >32 | >32 | >32 | 0 |
| cefepime/AVI | 16 to >32 | >32 | >32 | 0 |
a
Strains expressed VIM-1 (6), VIM-2 (4), VIM-4 (3), or NDM-1 (1). Strains tested included E. coli (4), E. cloacae (2), K. pneumoniae (4), P. aeruginosa (1), and A. baumannii (3).
b
MIC testing conducted using CLSI broth microdilution assay with BLI fixed at 4 μg/mL and cefepime titrated.
c
CLSI SDD breakpoint, M100, 2019.