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(A) H2O2 generation by heart mitochondria from adult mice as a function of the membrane potential. The conditions and the effects of various depolarizing agents (malonate, uncouplers [FCCP and SF6847], ADP, glucose, and creatine) are as described in Fig. 3A. (B and C) Membrane potential (B) and H2O2 generation (C) as a function of ADP concentration. *P < 0.01; **P < 0.001, for the effects of glucose or creatine.
