Fig. 2.

Interruption of complex N-glycan branching leads to the development of spontaneous sialadenitis. (A–C) Analysis of sialadenitis in aged (9 mo) Mgat5^−/− and WT mice. (Left) Representative images of salivary gland tissue sections and (Right) inflammatory score (mean ± SEM, n = 5; A), weight (mean ± SEM, n = 8; B), and number of ducts per square millimeter (mean ± SEM, n = 5; C) of submandibular salivary glands. (D) Quantification by flow cytometry of the average percentage of infiltrating cell populations of the whole salivary gland of aged (9 mo) Mgat5^−/− and WT mice (mean ± SEM, n = 8). *P < 0.05; **P < 0.01; ***P < 0.001, Student’s t test.