Table 2. Disease-associated mutations in human core ATG genes.

Gene	Yeast homologue	Disease	Reference
WDR45	Atg18/Atg21	NBIA	[81]
WDR45	Atg18/Atg21	SENDA (static encephalopathy of childhood with neurodegeneration in adulthood)	[82]
WDR45	Atg18/Atg21	BPAN (β-propeller protein-associated neurodegeneration)	[83,84]
ATG5	Atg5	Congenital ataxia, mental detardation, developmental delay	[85]