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Peptoids with different molecular architectures for DNA origami protection. (A) Chemical structures of peptoids designed to protect 3D OCs. PE1, PE2, and PE3 represent brush-type peptoids; PE4 and PE5 are block-type peptoids. (B) TEM image and schematic view (Inset) of the OC structure. (Scale bar, 50 nm.) (C) Schematic view showing the different surface coatings of the two types (“brush” and “block”) of peptoids on OCs proposed in this work, which results in varied protection effects.
