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Structure of retinal photoreceptors. RPGRORF15 is localized to the connecting cilium of the photoreceptors, tethered to the axoneme and the basal bodies by its interaction with other proteins such as RPGRIP1. Evidence suggests that RPGRORF15 regulates cargo trafficking between the inner and the outer segment, and for this function, its glutamylation by the enzyme TTLL5 is essential.
