Table 6.

Timing of surfactant: meta-analysis of three trials of poractant alfa (Curosurf)

Outcome	OR	95% CI	Adjusted OR a	95% CI
Severe RDS	0.55	0.38–0.79	0.50	0.33–0.74
Air leaks	0.54	0.35–0.82	—	—
Neonatal mortality	0.52	0.35–0.76	0.47	0.30–0.73
BPD in 28-day survivors	0.67	0.45–1.00	0.54	0.34–0.86
Meta-analysis of prophylaxis versus rescue (n=671)
Overall IVH	0.65	0.47–0.90
Severe IVH	0.56	0.35–0.89
Severe IVH (outborn)	0.11	0.02–0.49

Abbreviations: BPD, ; IVH, intraventricular hemorrhage; RDS, respiratory distress syndrome.

Egberts et al.⁶⁰

Walti et al.⁶¹

^aAdjusted for gender, birth weight and prenatal steroids.