Table 2.

Glia to neuron ratio (GNR) in various brain regions associated with oxidative stress-related CNS disorders

Brain region	GNR	Citations for GNR	Associated disorders	Citations for disorders
Cortex (monkey)	1:1	[108]	Female bias: AD, MD, ANX Male bias: PD, SZ, ASD	[109–114]
Cortex (human)	4:1	[115]
Cortex (rat)	1:1	[116]
Striatum (mouse)	1:17	[117]	Female bias: MD	[110, 111, 113]
			Male bias: PD, SZ, ASD
Basal ganglia (human)	1:2	[118]	Female bias: MD,	[110, 111, 113, 114]
			Male bias: PD, SZ, ASD
Substantia nigra pars compacta (mouse)	1:9	[119]	Female bias:—	[110, 120]
			Male bias: PD, SZ
Thalamus (human)	17:1	[121]	Female bias: MD	[111, 113, 122]
			Male bias: PD, SZ
Hippocampus overall (mouse)	1:1	[117]	Female bias: AD, MD, ANX, Male bias: PD, SZ, ASD	[109–114]
CA1 (mouse)	1:2	[117]
CA3 (mouse)	1:3	[117]
Locus coeruleus (human)	27:1	[123]	Female bias: AD, MD	[110–112, 124, 125]
			Male bias: PD, ANX
Amygdala basolateral (rat)	1:7	[117, 126]	Female bias: AD, MD, ANX,	[110, 112, 114, 127]
			Male bias: PD, ASD
Spinal cord (rat)	1:6	[128]	Female bias:—	[110]
			Male bias: PD
Cerebellum (mouse) Cerebellum (human)	1:1 1:4	[117] [115]	Female bias:—	[110, 114]
			Male bias: PD, ASD

AD Alzheimer’s disease, PD Parkinson’s disease, MD major depression, ANX anxiety disorders, SZ schizophrenia, ASD autism spectrum disorders