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. 2020 Mar 30;19:69. doi: 10.1186/s12943-020-01187-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — PVT1 transcript alignment in UCSC Genome Browser on Human Dec. 2013 (GRCh38/hg38) Assembly. 8q24.21 region encodes for PVT1 and circPVT1. The sequence of PVT1 transcript with the largest number of exons is shown in the upper part of the figure. PVT1 isoforms and circPVT1 with the highest expression in the hematopoietic system, are shown in the lower part of the figure (from the top: NONHSAT255418.1, NONHSAT255436.1, NONHSAT255445.1). The secondary structure of circPVT1 is reported as discovered by Liu et al. [12]. The rectangles represent the exons