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. 2020 Mar 30;19:69. doi: 10.1186/s12943-020-01187-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Model of PVT1 and circPVT1 pro-tumorigentic functions in hematological malignancies. PVT1 and circ-RNA act as a miRNA sponge and regulate the energy metabolism, protein stability, cell cycle progression through a variety of pathways, thus promoting cell proliferation, immune suppression and inhibiting cell death (green represents induction, red indicates suppression, dashed line shows indirect and not specified mechanisms; ROS: reactive oxygen species; RBPs: RNA-binding proteins, including EIF4A3, U2AF65, AGO2, AUF1, DGCR8, FUS, HNRNPC, PTB, TAF15, TDP43, TIA1, TIAL1, LIN28A)