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IRF6 is required for SPECC1L expression in the palate. Immunostaining of coronal embryonic palate sections at E15.5. (A) SPECC1L is expressed widely (red) in the palate in WT mice. (B) Irf6 null mice exhibit abnormal oral adhesions throughout the oral cavity and loss of SPECC1L expression. (C) These phenotypes are rescued with transgenic expression of Irf6 in the oral ectoderm using a Keratin 14 promoter. Grayscale insets are of red channel. Scale bar is 100 μm.
