Figure 3.

ATAC-seq reveals an altered chromatin state in DS astrocytes, with differential chromatin accessibility in the promoters of cell adhesion and ECM genes. (A) Plot displaying the differentially accessible peaks in DS astrocytes revealing both an increase and decrease in chromatin accessibility. (B) Violin plots of the correspondence between ATAC-seq and RNA-seq data sets show that upregulated and downregulated genes identified by RNA-seq do not have differential accessibility at promoters in CTL and DS astrocytes. (C) Top five biological processes and cellular components enriched in genes with differentially accessible promoters according to GO analysis. Bars encode number of genes associated with the ontology term and are colored by –log10 of adjusted P-value.