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Histological sections of primary tumor from 4T1 breast tumor-bearing female BALB/c mice treated with SpHL, DOX, SpHL-DOX, or SpHL-DOX-Fol stained by hematoxylin & eosin. (A) SpHL-treated primary tumor. (B) DOX-treated primary tumor. (C) SpHL-DOX-treated primary tumor. (D) SpHL-DOX-Fol-treated primary tumor. The black arrows indicate tumor necrosis areas. The black head arrows indicate tumor area. Amplification of 2 ×.
