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. Author manuscript; available in PMC: 2020 Dec 19.
Published in final edited form as: Mol Cell. 2019 Oct 3;76(6):965–980.e12. doi: 10.1016/j.molcel.2019.08.030

Figure 5. Stage-specific induction of H3K27M indicates an oligodendrocyte-lineage cell of transformation.

Figure 5.

A) Schematic for differentiation from human pluripotent stem cells (hPSC) to multipotent NPC, pre-OPC, and eOPC stages.

B) Comparison of H3K27Ac enrichment at all enhancers at each differentiation stage without H3K27M induction. Y-axis shows primary DIPG log2(mean H3K27Ac enrichment) and x-axis shows NPC, pre-OPC, or eOPC log2(mean H3K27Ac enrichment) (n = 2).

C) H3K27Ac genome tracks at oligodendroglial lineage markers OLIG1/2 and NKX2.2. Samples from each primary DIPG group are shown overlaid as a single track. X-axis represents genomic location and y-axis represents RPM.

See Figure S5.