Figure 6.

Histograms of (a) and (b) pairing probabilities of WT and mutated folds (batch size s  =  720 nt, ∼20% of the genome size) and (c) and (d) number of high-degree branching points (6 branches or more) of BMV RNA2 and phage MS2 genomes. Folds obtained with different mutation schemes result in smaller pairing probabilities compared to the WT folds; this difference is most prominent in the case of disperse mutations. Disperse mutations also tend to slightly reduce the number of high-degree branching points compared to other mutation schemes and WT sequences. Other global structural properties, such as average duplex size or average degree of branching, show no difference between the WT and mutated folds.