. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: Radiother Oncol. 2019 Nov 9;144:37–45. doi: 10.1016/j.radonc.2019.10.003

Table 2.

Treatment Characteristics

Reference	Treatment given	RT Dose	Chemotherapy	Median time between neoadjuvant therapy and surgery in weeks	Type of surgery
Chmielik et al. ²⁷, Rutkowski et al.²⁶	Chemoradiation ^*	50.4 Gy / 1.8 Gy fx/day; 5 fx per week	5-Fluorouracil and leucovorin	5.6 (range 3.1-18.6)	Abdominoperineal (n=35), Low anterior (n=48), Hartmann (n=3)
Guedj et al. ²⁸	Chemoradiation	45-50 Gy; 5 fx per week over 5-6 weeks	5-Fluorouracil -based	9 (range 1.3-18)	Proctectomy with TME (n=118), Abdominoperineal (n=6)
Guillem et al. ²⁴	Chemoradiation	48.6 Gy-54 Gy / 1.8 Gy fx/day, with 3.6 Gy boost to tumor; 5 fx per week	5-Fluorouracil -based	6.9 (range 2.7-22.1)	Abdominoperineal (n=22), Low anterior (n=87)
Perez et al.²³	Chemoradiation	50.4-54 Gy / 1.8Gy fx/day	5-Fluorouracil -based	16.5 (range 6-160)	TEM

Only the chemoradiation arm in Chmielik et al.²⁷ was analyzed for the purpose of this meta-analysis.