Table 4.

Predictive Factors

Factor		Percentile	Microscopic intramural spread (mm)	95% Confidence intervals	Comparison	Statistical significance ***
Tumor grade*	1	90	5	0 - 8	1 vs. 2	no
		95	7.8	2 - 10	1 vs. 3	no
	2	90	4.2	1 - 9	2 vs. 3	no
		95	9	3.2 - 11
	3	90	4.5	0 - 6
		95	NA	NA
Vascular invasion**	no	90	2	0 - 4	no vs. yes	no
		95	5.3	2 - 8
	yes	90	0	0 - 2.4
		95	1.2	0 - 20
Perineural invasion**	no	90	0.5	0 - 3	no vs. yes	no
		95	5	2 - 6.75
	yes	90	1.8	0 - 10
		95	9.65	0 - 20
ypT stage	1	90	0	0 - 2.1	ypT1 vs. ypT2	p < 0.001
		95	1.05	0 - 7.05
	2	90	5	3 - 6
		95	6.6	5 - 8	ypT2 vs. ypT3-4	p = 0.010
	3-4	90	3	1 - 3
		95	4.5	3 - 9.5	ypT1 vs. ypT3-4	p = 0.008
Time interval CRT - surgery (weeks) ****	≤ 8	90	3	2 - 5	≤ 8 vs. > 8	no
		95	5	3 - 8.7
	8 - 12	90	0.6	0 - 5.3	≤ 8 vs. > 12	p = 0.002
		95	5.15	0 - 11.5
	> 12	90	7	4 - 9	≤ 12 vs. > 12	p < 0.001
		95	8.5	6 - 9	≤ 8 vs. 8-12 vs. > 12	p < 0.001

^*Only data by Perez et al.²³ and Guedj et al.²⁸

^**Data not available for Chmielik et al.²⁷ and Rutkowski et al.²⁶

^***Statistical significance level is p = 0.05

^****Comparison using Kruskal-Wallis test