nr(t) |
Total number of cases in region r at time t
|
Dr(t) |
Number of notified cases in region r at time t
|
ρ |
Reporting rate, Dr(t) = ρnr(t) |
Nr
|
Population of region r
|
|
Number of secondary transmissions among all notified cases Dr(t) in region r at time t
|
sr(t) |
Number of notified secondary cases in region r at time t
|
|
Rate of generation of sporadic cases in region r at time t
|
|
Rate of generation of sporadic cases in region r at time t obtained from notified cases,
|
Rr(t) |
Reproduction ratio for human-to-human transmission in region r at time t
|
αr
|
Geographical variation of the rate of generation of sporadic cases in region r,
|
βr
|
Geographical variation of the reproduction ratio for human-to-human transmission in region r, Rr(t) = βrR(t) |
qsp,1, qsp,2
|
Baseline level and peak level of the spline function assumed to model
|
R1, R2, R3
|
Three levels of the stepwise function assumed to model Rr(t) |