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Topologies of the TM region of the to-date known viral channel-forming proteins. (A) A single TM domain [e.g., M2 (influenza A), Vpu (HIV-1), 6K (alphavirus)]. The proteins have a parallel alignment. (B) Two TM domains as proposed for p7 (HCV) or 2B (Polio). (C) Three TM domains proposed for 3a (SARS-CoV). (D) Kcv model based on sequence homology (Plugge et al., 2000) to KcsA channel (Doyle et al., 1998).
