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. 2013 May 24;5(3):1013–1030. doi: 10.1016/j.jff.2013.04.018

Table 2.

List of various classes of compounds and their pharmacological activities reported in Cordyceps sinensis.

Constituents Pharmacological functions References
Polysaccharides
Antioxidant activity Li et al., 2001a, Yu et al., 2006a, Yu et al., 2006b and Zhang et al. (2011)
CS-F30 and CS-F10 Hypoglycemic and hypolipidemic effect Kiho, Ookubo, Usui, Ukai, and Hirano (1999), Kiho et al. (1996)
Polysaccharide fraction from CS (PSCS) Antileukemic Chen et al. (1997)
Mannoglucan Cytotoxic activity Wu et al. (2007b)
Exo-polysaccharides Immunomodulatory and antitumour effects Yang et al., 2005, Zhang et al., 2005 and Zhang, Li, Qiu, Chen, and Zheng (2008)
Acid polysaccharide fraction (APSF) Immunomodulatory effect Chen, Zhang, Wenbin Shen, and Wang (2010) and Chen et al. (2012)
Heteropolysaccharides (PS-A) Hypercholestrolemia Kim (2010)



Nucleosides
Adenosine Immunomodulatory & pharmacokinetic effects, cardioprotection Kim (2010) and Yu, Zhao, Zhu, and Li (2007)
Guanosine Immunomodulatory effects Kim (2010)
Cordycepin Anti-cancer effects, pharmacokinetic effect, immunomodulatory effect, antileukemic Kodama et al., 2000, Nakamura et al., 2006, Pao et al., 2012, Tsai et al., 2010,Yoshikawa et al. (2011) and Zhou et al. (2008)
Sterols
Ergosterol Anti-cancer effects Matsuda et al. (2009) and Wu et al. (2007a)
β-Sitosterol Anti-cancer effects Matsuda et al. (2009) and Wu et al. (2007a)
5a,8a-Epidioxy-24(R)-methylcholesta-6,22-dien-3b-d-glucopyranoside Anti-cancer effects Bok et al. (1999)
5,6-Epoxy-24(R)-methylcholesta-7,22-dien-3b-ol Anti-cancer effects Bok et al. (1999)
5α,8α-Epidioxy-22E-ergosta-6,22-dien-3β-ol Anti-cancer effects Matsuda et al. (2009)
5α,8α-Epidioxy-22E-ergosta-6,9(11),22-trien-3β-ol Anti-cancer effects Matsuda et al. (2009)
5α,6α-Epoxy-5-ergosta-7,22-dien-3β-ol Anti-cancer effects Matsuda et al. (2009)
Protein constituents Hypotensive and vasorelaxant activities Chiou et al. (2000)



Proteins
CSAP Anti-bacterial activity Zheng et al. (2006)
Cordymin (peptide) Anti-inflammatory and anti-nociceptive activities Qian et al. (2012)
Cordycedipeptide A (cyclodipeptide) Cytotoxic activities Jing et al. (2005)
Cordyceamides A and B Cytotoxic activities Jia et al. (2009)