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Inhibitory effect (IC50) of EGCG and its derivatives against HCV protease.a
| Compounds | EGCG | 1 | 2 | 3 | 4 | Embelin |
|---|---|---|---|---|---|---|
| IC50 (μM) | >200 | 0.13 | 0.006 | 0.006 | 0.98 | 10.19 |
| RSD (%) | 5.5 | 1.8 | 3.4 | 3.0 | 4.4 | 9.0 |
RSD: relative standard deviation.
Compounds 1, 2 and 3 are EGCG tetraesters of SA, EPA and DHA, respectively; compound 4 is EGCG-octabutyrate.
