Table 1. Comparison of HAL with other agent-based modeling frameworks commonly used in tissue modeling as of December 2019.

Features are marked according to whether there exists a built-in user accessible implementation.

Feature	HAL	Cha	Rep	Mas	Net	Phy	Cel	Bio	Tim	Yal	Epi	Com	Mor	TST
On-Lattice ABMs	✔	✔	✔	✔	✔								✔
Off-Lattice Point ABMs	✔	✔	✔	✔	✔
Off-Lattice Spherical ABMs	✔	✔				✔	✔	✔	✔	✔	✔
Voronoi Tesselation ABMs		✔	✔
Cellular Potts ABMs		✔										✔	✔	✔
Multinomial Population ABMs [35]	✔
Diffusion PDEs	✔	✔	✔		✔	✔	✔	✔	✔	✔	✔	✔	✔	✔
Advection PDEs	✔	✔					✔					✔	✔
SBML Compatible [36]						✔					✔	✔	✔
Real-Time Visualization	✔		✔	✔	✔		✔				✔		✔	✔
Single-Model Parallelization		✔	✔			✔	✔	✔	✔	✔	✔	✔	✔	✔
Windows Compatible	✔	✔	✔	✔	✔	✔	✔		✔		✔	✔	✔	✔
Mac Compatible	✔	✔	✔	✔	✔	✔				✔		✔	✔	✔
Linux Compatible	✔	✔	✔	✔	✔	✔	✔	✔	✔	✔	✔	✔	✔	✔
User-Facing Programming Language*	J	C	R	J	N	C	C	C	C	U	I	P	M	C

Framework Abbreviations: HAL:Hybrid Automata Library, Cha:Chaste, Rep:Repast, Mas:Mason, Net:Netlogo, Phy:Physicell, Cel:CellSys, Bio:Biocellion, Tim:Timothy, Yal:Yalla, Epi:Episim, Com:CompuCell3D, Mor:Morpheus, TST:Tissue Simulation Toolkit

* User-Facing Programming Languages: J: Java, C: C/C++, R: Relogo/Java/Groovy, N: NetLogo Programming Language, U: CUDA/C++, I: Graphical Interface, P: Python/XML, M: Morpheus model description language