Table 3.

Clinical status of patients with and without viruses at pulmonary exacerbation.

	Virus-positive	Virus-negative	p value
	(n = 26)	(n = 17)
Predicted FEV1a	17 (65.4)	15 (88.2)	0.447
– Median (IQRb)	48 (39.5–64.8)	60 (44–79)	0.213
Received antibiotics	18 (69.2)	11 (64.7)	0.335
Hospitalized	9 (34.6)	5 (29.4)	0.504
CFCSc	25 (96.1)	16 (94.1)	0.234
– Mean (range)  – Median (IQR)	27.2 (19–39)	23.7 (17–41)	0.061
	27 (18–30)	24 (18–27)	0.041
CFQ-Rd (physical)	18 (69.2)	15 (88.2)	0.405
– Mean (range)  – Median (IQR)	58.3 (33.3–78.2) 53.4 (0–100)	79.2 (61.1–91.7) 75.3 (11.1–100)	0.028 0.030
Sputum IL-8	11 (42.3)	6 (35.3)	0.386
– Median (IQR), pg/ml	1785.8 (779–2936.9)	1403 (336–2448.5)	0.615
Sputum neutrophil percentage	11 (42.3)	5 (29.4)	0.553
– Median (IQR)	99.5 (99.3–99.9)	99. 3 (99–99.5)	0.402
Sputum neutrophil count	11 (42.3)	5 (29.4)	0.553
– Median (IQR), μ/ml	398 (397–399)	398 (396–399.5)	0.863
Sputum neutrophil elastase	11 (42.3)	6 (35.3)	0.386
– Median (IQR), μ/ml	0.2 (0.1–0.3)	0.3 (0.1–0.5)	0.421
Sputum total bacterial density	8 (30.8)	7 (41.2)	0.449
– Mean (SD)e, colony forming units/mL	3.9 × 107 (6.9 × 107)	1.8 × 109 (4.5 × 109)	0.299
Staphylococcus aureus bacterial density	5 (19.2)	5 (29.4)	0.350
– Mean (SD), colony forming units/mL	1.3 × 107 (2.6 × 107)	5.9 × 107 (8.0 × 107)	0.249
Pseudomonas aeruginosa bacterial density	2 (7.7)	2 (11.8)	0.261
– Mean (SD), colony forming units/mL	1.3 × 108 (1.0 × 108)	6.0 × 109 (8.5 × 109)	0.431
Haemophilus influenzae bacterial density	1 (3.8)	–	–

Note. Data are n (%) unless otherwise indicated. * No observations.

^aForced expiratory volume in one second at exacerbation.

^bInterquartile range (25th–75th percentile).

^cCystic fibrosis clinical score.

^dCystic Fibrosis Questionnaire-Revised.

^eStandard deviation.