Table 2.
Viral proapoptotic proteins.
| Virus | Protein | Partners | Intracellular Localization |
|---|---|---|---|
| EBV | BALF1 | Bax, Bak | Cytoplasm |
| HPV | E1^E4 | Cytokeratins | Mitochondria, microtubule-associated |
| E6 | p53 | Cytoplasm | |
| E7 | – | Cytoplasm | |
| HCV | NS3 | Caspase-8 | Cytoplasm |
| NS4A | – | Mitochondria | |
| VSV | M | Transcription of Bcl-2 family members | Cytoplasm, nucleus |
| P | – | Cytoplasm | |
| IAV | PB1-F2 | VDAC1, ANT3 | Mitochondria (inner membrane) |
| AEV | VP3 | – | Mitochondria |
| 2C | Caspase-9, caspase-3 | Mitochondria | |
| SARS-CoV | 7A | Bcl-xL | Golgi apparatus |
| NSP15 | – | Cytoplasm | |
| HIV-1 | Vpr | ANT, VDAC | Mitochondria, Cytoplasm, nucleus |
| Tat | – | Cytoplasm, nucleus | |
| Nef | – | Cytoplasm | |
| Protease | – | Cytoplasm | |
| HTLV-1 | p13II | – | Mitochondria (inner membrane) |
| HBV | HBx | VDAC3, Hsp60 | Mitochondria |
Abbreviations: EBV, Epstein-Barr virus; HPV, human papiloma virus; HCV, hepatitis C virus; VSV, vesicular stomatitis virus; IAV, influenza A virus; AEV, avian encephalomyelitis virus; SARS-CoV, severe acute respiratory syndrome corona virus ; HIV-1, human immunodeficiency virus type 1; HTLV-1, human T lymphotropic virus type 1; HBV, hepatitis B virus.