Table 1.
Hydrolysis of biologically active peptides by ACE2
| Peptide sequence | |
|---|---|
| Apelin-13 | QRPRLSHKGPM P⇑ F |
| Angiotensin I | DRVYIHPFH ⇑ L |
| Angiotensin II | DRVYIHP ⇑ F |
| des-Arg9-Bradykinin | RPPGFS ⇑ F |
| β-Casomorphin-(1–7) | YPFVEP ⇑ I |
| Dynorphin A-(1–13) | YGGFLRRIRPKL ⇑ K |
| Ghrelin (C terminus shown) | …ESKKPPAKLQP ⇑ R |
| Neurotensin-(1–8) | pELYENKP ⇑ R |
| Neurotensin-(1–11) | pELYENKPRRP ⇑ Y |
The major peptides that are hydrolysed by ACE2 are shown with their amino acid sequence. An arrow indicates the site of cleavage. pE is pyroglutamyl.