Table 6.
Gene sets enrichment analysis of the 3052 DEGs in the epithelium
| Enriched gene sets | Enrichment | NES | NOM p-val | FDR q-val |
|---|---|---|---|---|
| COAGULATION | Positive | 2.4593391 | 0 | 0 |
| COMPLEMENT | Positive | 2.3820252 | 0 | 0 |
| TNFA SIGNALING VIA NFKB | Positive | 2.260513 | 0 | 0 |
| INFLAMMATORY RESPONSE | Positive | 2.2356772 | 0 | 0 |
| XENOBIOTIC METABOLISM | Positive | 2.1790328 | 0 | 0.000179012 |
| HYPOXIA | Positive | 1.9205347 | 0 | 0.008392723 |
| APOPTOSIS | Positive | 1.8877827 | 0.001414427 | 0.009475978 |
| INTERFERON GAMMA RESPONSE | Positive | 1.8587548 | 0 | 0.011746863 |
| KRAS SIGNALING UP | Positive | 1.8500544 | 0.004172462 | 0.011368177 |
| EPITHELIAL MESENCHYMAL TRANSITION | Positive | 1.6994203 | 0.004178273 | 0.03300058 |
| ANGIOGENESIS | Positive | 1.4216607 | 0.09548611 | 0.15824698 |
| APICAL JUNCTION | Positive | 1.2970207 | 0.15987934 | 0.27779698 |
| P53 PATHWAY | Positive | 1.2064549 | 0.21958457 | 0.38236877 |
| E2F TARGETS | Negative | –3.7750194 | 0 | 0 |
| G2M CHECKPOINT | Negative | –3.4905815 | 0 | 0 |
| MYC TARGETS V1 | Negative | –2.5305622 | 0 | 0 |
| MITOTIC SPINDLE | Negative | –2.4694543 | 0 | 0 |
| ESTROGEN RESPONSE LATE | Negative | –1.8183266 | 0 | 0.009814334 |
| DNA REPAIR | Negative | –1.0963912 | 0.32970026 | 0.43156412 |
| MTORC1 SIGNALING | Negative | –0.7685945 | 0.8393939 | 0.88358915 |
| ESTROGEN RESPONSE EARLY | Negative | –0.7567437 | 0.8778878 | 0.8235289 |