Table 7.
Canonical pathway analysis of the epithelium-specific DEGs ising IPA
| Ingenuity canonical pathways | -log (P-value) | Z-score | Molecules in dataset |
|---|---|---|---|
| Dermatan sulfate biosynthesis | 3.67 | — | CHST1,HS6ST1,CSGALNACT2,SULT1A1,CHST10,HS6ST3,DSEL,SULT2B1 |
| Cholesterol biosynthesis i | 3.46 | — | FDFT1,EBP,MSMO1,CYP51A1 |
| Chondroitin sulfate biosynthesis (late stages) | 3.41 | — | CHST1,HS6ST1,CSGALNACT2,SULT1A1,CHST10,HS6ST3, SULT2B1 |
| Superpathway of cholesterol biosynthesis | 3.03 | — | FDFT1,EBP,MSMO1,HMGCS1,CYP51A1 |
| Chondroitin sulfate biosynthesis | 3.01 | — | CHST1,HS6ST1,CSGALNACT2,SULT1A1,CHST10,HS6ST3, SULT2B1 |
| Osteoarthritis pathway | 2.18 | 2.496 | CXCL8,MTOR,FRZB,SMAD3,BMP2,ITGA2,BMPR2,WNT16,SOX9,MEF2C,HES1,ACAN,MMP1 |
| Cholecystokinin/Gastrin-mediated Signaling | 2.15 | 2.121 | GAST,MAPK14,RHOB,MEF2D,CREM,MEF2C,GNA13,PRKCG |
| Il-8 signaling | 2.03 | 2.309 | CXCL8,PIK3CA,MTOR,FLT1,RHOB,HBEGF,CXCL1,GNA13,KDR,MAP4K4,PRKCG,EIF4EBP1 |
| TGF-β signaling | 1.97 | 1.342 | IRF7,MAPK14,BMP2,SMAD3,BMPR2,TGIF1,INHBA |
| PTEN signaling | 1.74 | -2.121 | PIK3CA,FLT1,ITGA2,PREX2,BMPR2,KDR,BCL2L11,PDGFRB |