Skip to main content
. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Neurosci Res. 2019 Jul 29;97(12):1606–1623. doi: 10.1002/jnr.24505

Fig. 1.

Fig. 1.

Circadian deficits in locomotor activity in Q175 mutant mice. (A) Representative double plotted actograms of wheel running activity from age-matched WT (left), Het Q175 (middle) and Hom Q175 Hom (right) mice under 12:12 light:dark (LD) and constant darkness (DD) are shown. The white/black bars on top indicate the LD cycle, and gray shading indicates darkness. Successive days of activity are plotted from top to bottom. An analysis of the data the data collected from 12 month old mice in DD found significant alterations in the wheel running activity (B), power (C), and cycle-to-cycle variation (D) in activity onset. The free-running period did not vary with genotype although the Hom Q175 exhibit higher variation (E). Individual data points are shown with WT (black circle, n=8), Het Q175 (grey triangle, n=7) and Hom Q175 (red diamonds, n=8). The bar graphs show means and standard deviation from the mean. The asterisk indicates significant difference (P < 0.05) from WT. Data from Loh et al., 2013.