Fig 3:

Q175 mice exhibited reduced amplitude circadian rhythms of the activity as measured by telemetry. Whereas wheel-running represents voluntary motor activity, telemetry captures all movement. All of the mice exhibited significant subjective day-night differences in activity. (A) The activity of young mice (3–4 months) was unaltered during the subjective day but significantly reduced throughout the subjective night in the Het and Hom Q175 compared to WT. (B) At middle age (9–12 mo), a very similar pattern is observed. Individual data points are shown with WT (black circle, n=6), Het Q175 (grey triangle, n=10) and Hom Q175 (red diamonds, n=9). Data from Cutler et al., 2017.