Fig. 4:

Hom Q175 mice exhibited disrupted ability to maintain core body temperature (CBT) by middle age. All of the mice exhibited significant subjective day-night differences in CBT. (A) There were no differences between the genotypes the rhythms in CBT in the young adult mice (3–6 mo). (B) By middle age (9–12 mo), the Hom Q175 exhibited reduced CBT in the early subjective day. The mutant mice exhibited episodes of hypothermia that were most severe in the Hom Q175. Individual data points are shown with WT (black circle, n=6), Het Q175 (grey triangle, n=10) and Hom Q175 (red diamonds, n=9). Data from Cutler et al., 2017.