Fig. 5:

Q175 mice exhibited altered circadian rhythms in resting HR by middle age. (A) There were no differences in the rhythms in HR between the genotypes in the young adult mice (3–6 mo). (B) By middle age (9–12 mo), the Hom Q175 show low resting HR in the early subjective day. At other phases the HR of the Hom mutants trended lower but these effects were not significant. Individual data points are shown with WT (black circle, n=6), Het Q175 (grey triangle, n=10) and Hom Q175 (red diamonds, n=9). Data from Cutler et al., 2017.