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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Neurosci Res. 2019 Jul 29;97(12):1606–1623. doi: 10.1002/jnr.24505

Fig. 7:

Fig. 7:

Q175 mice exhibited reduced spontaneous firing rate in SCN during the day. (A) Using the current-clamp recording technique in the whole-cell configuration, the SFR in dSCN neurons was measured during the day and night. The Q175 dSCN neurons did not exhibit the day/night difference in SFR seen in WT neurons. Firing rate was measured in the day (WT, n=12 neurons, Het Q175, n=21, Hom Q175, n=22) and night (WT, n=23 neurons, Het Q175, n=17, Hom Q175, n=23). (B) BK currents measured in Het Q175 dSCN neurons were significantly larger than those in WT during the day (ZT 5–7). Two-way ANOVA was used to identify significant effects of genotype and/or voltage step magnitude on evoked currents. There were significant effects of genotype on the BK current at the 60 and 80 mV steps. BK current were measured in WT (n=11 neurons) and Het Q175 (grey triangle, n=9). Data from Kuljis et al., 2018.