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Pretreatment with the FOXO1 inhibitor preserved mitochondrial integrity following DOX challenge. NRCMs were treated with DOX (1 μm) in the presence of the FOXO1 inhibitor AS1842856 (1 μm) or vehicle for 48 h. Mitochondrial membrane potential was then assessed by JC-1 staining. JC-1 monomers (green) indicate damaged mitochondria, whereas J-aggregates (red) indicate healthy mitochondria. Two-way ANOVA with Sidak test. *, p < 0.05; **, p < 0.01. Scale bar = 100 μm.
