Figure 6.

Concentration dependence of oxime reactivation of sarin- (A), paraoxon- (B), cyclosarin- (C), and VX-inhibited (conjugated) (D) hAChE. Shown is dependence for the LG bis-oximes LG-703 (black circles), LG-804 (black triangles), LG-700 (white circles), LG-750 (white triangles), LG-747 (white squares), LG-823 (gray inverted triangles), LG-829 (gray diamonds) compared with RS194B (stars and dashed curves). Curves for piperidine-based bis-oximes LG-823 and LG-829 are gray. All measurements (n ≥ 3; error bars show individual k_obs spread) were at 37 °C in 0.10 m phosphate buffer, pH 7.4, and with up to 1% DMSO. Curves were calculated by nonlinear regression from the relationship k_obs = k₂/(1 + K_ox/[oxime]) as described previously (7), and resulting constants are listed in Table 3.