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X-ray structure of homopiperazine-based bis-oxime LG-703 bound in the active-center gorge of Apo-hAChE. Orange/green water-accessible Connolly surface of hAChE is removed in part to reveal the gorge interior. Catalytic triad side chains (Ser-203, His-447, and Glu-334) are rendered in yellow sticks. The choke point narrow is defined by Tyr-124 and Tyr-337.
