Table 6. Multivariate Cox Regression analysis of prognostic factors and survival.

Variable	Progression Free Survival			OS
	HR	95% CI	p value	HR	95% CI	p value
Age (<50 versus ≥50 years)	1.00	0.98–1.03	0.50	1.01	0.98–1.03	0.37
ECOG Performance status (1 versus >1)	1.84	1.12–3.01	0.01	1.61	0.99–2.63	0.05
Tumors contacting SVZ (yes vs no)	0.93	0.53–1.63	0.80	0.82	0.47–1.42	0.48
Surgery (GTR versus < GTR)	1.45	0.59–3.57	0.40	0.22	0.71–4.15	0.22
Concurrent TMZ (yes versus no)	0.34	0.12–0.92	0.03	0.33	0.12–0.91	0.03
Adjuvant TMZ (yes versus no)	3.36	1.68–6.73	0.00	4.15	2.04–8.41	0.00
iSVZ (<58.0 Gy versus ≥58.0 Gy)	0.85	0.40–1.79	0.67	0.80	0.38–1.70	0.57

ECOG PS: Eastern Cooperative Oncology Group Performance Status; SVZ: Sub ventricular zone; i- ipsilateral, TMZ – Temozolomide; GTE – Gross total rescection