Table 4.
Reports of severe or fatal disease in arenavirus-infected IFN-deficient mice.
| Virus | Strain | Knockout (background) | Outcome | References |
|---|---|---|---|---|
| LASV | rJosiah | STAT1−/− (129S6/SvEv) | L | Yun et al. (2013) |
| LF2384-NS-DIA-1 | STAT1−/− (129S6/SvEv) | L | Yun et al. (2013) | |
| STAT1−/− (129S6/SvEv) | PL | Yun et al. (2015) | ||
| LV2350-NS-DIA-1 | STAT1−/− (129S6/SvEv) | PL | Yun et al. (2015) | |
| BA366 | IFNAR−/− B6 (C57BL/6)a | L | Oestereich et al. (2016) | |
| B6 IFNAR−/− (C57BL/6)a | PL | Oestereich et al. (2016) | ||
| IFNAR−/− IFNAR−/− (C57BL/6)a | PL | Oestereich et al. (2016) | ||
| MACV | Carvallo | STAT1−/− (129S6/SvEv) | L | Bradfute et al. (2011) |
| IFN α/β/γR−/− (129) | L | (Koma et al., 2016, 2015) | ||
| JUNV | Romero | IFN α/β/γR−/− (129/SvPAS) | L | Kolokoltsova et al. (2010) |
| TCRV | TRVL 11573 | IFN α/β/γR−/− (129/SvPAS) | L | Gowen et al. (2010) |
Studies reporting severe (PL, partially lethal; < 100% mortality at all doses and by all inoculation routes attempted in study) or fatal disease (L, lethal; 100% mortality achieved with at least one virus dose and inoculation route combination).
TCRV, Tacaribe virus.
a
Chimeric mice generated by transplantation of wild-type bone marrow cells into irradiated mice (indicated as background with transplanted bone marrow origin in superscript).