Table 5.
Reports of severe or fatal disease in CCHFV-infected IFN-deficient mice.
| CCHFV Strain | Knockout (background) | Outcome | References |
|---|---|---|---|
| IbAr10200 | STAT1−/− (129S6/SvEv) | L | Bente et al. (2010) |
| IFNAR−/− (129Sv/Ev) | L | Dowall et al. (2016) | |
| IFNAR−/− (129 Sv/Ev) | L | Bereczky et al. (2010) | |
| IFNAR−/− (C57BL/6) | L | Zivcec et al. (2013) | |
| Afg-09 2990 | IFNAR−/− (129Sv) | L | Oestereich et al. (2014) |
| Hoti | IFNAR−/− (C57BL/6) | L | Hawman et al. (2018) |
| Turkey-200406546 | IFNAR−/− (C57BL/6) | L | Spengler et al. (2019) |
| Turkey-200406546 | STAT1−/− (129S6/SvEv) | L | Rodriguez et al. (2019) |
| Ank-2 | IFNAR−/− (129S7/SvEvBrd) | L | Farzani et al. (2019a) |
| Ank-15 | IFNAR−/− (129S7/SvEvBrd) | L | Farzani et al. (2019a) |
| Ank-16 | IFNAR−/− (129S7/SvEvBrd) | L | Farzani et al. (2019a) |
| UAE | IFNAR−/− (C57BL/6) | PL | Spengler et al. (2019) |
| Oman-199723179 | IFNAR−/− (C57BL/6) | PL | Spengler et al. (2019) |
Studies reporting severe (PL, partially lethal; < 100% mortality at all doses and by all inoculation routes attempted in study) or fatal disease (L, lethal; 100% mortality achieved with at least one virus dose and inoculation route combination) in IFN-deficient mice.