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. 2019 Dec 19;105(5):1427–1434. doi: 10.1210/clinem/dgz277

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© Endocrine Society 2019.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Circulating GDF15 is increased in primary adrenal insufficiency. (A) Early morning serum cortisol levels are significantly lower in 10 patients with Addison’s disease (AD) following withdrawal of maintenance glucocorticoid therapy when compared to a cohort of healthy matched control participants (n = 10). (B) Serum GDF15 measured in parallel with cortisol sampling was significantly higher within the steroid deficient Addison’s disease cohort than in the control group. Data presented as mean ± standard deviation and compared using an unpaired t-test. *P < .05 and ****P < .0001.